Thomas A. Smiley


Norovirus GII.4/CIN-3 characterization challenge, 2022

“I took the plunge and got infected with norovirus to help better understand the disease. To me, it was a relatively simple request: my health, temporarily, in return for scientific advancement.”

Mallory Admire


Shigella flexneri 2a SF2a-TT15 vaccine challenge, 2022

“Nobody wants to get sick (especially with infectious diseases like dysentery!) but I’m hopeful that by people like me volunteering for human challenge studies, medical advances can be made to help protect those most vulnerable.”

Paresh Patel


SARS-CoV-2 (Wuhan strain) reinfection challenge study, 2021 (Paresh was the study’s first participant!)

“The deep nasal swabs and my initial fear of needles were awful!! But was a small sacrifice to hopefully enable us to combat Covid-19 better.”

Dominique Meyer


Shigella flexneri 2a SF2a-TT15 vaccine challenge, 2022

“Medical research is very important to me from both a professional and personal standpoint. Participating in a challenge study was a great way to support research in a different way that I hope can provide a broad clinical impact and improve global health outcomes.”

Alastair Fraser-Urquhart


SARS-CoV-2 (Wuhan strain) challenge study, 2021

“Challenge studies show us that there are people who are truly happy to take on physical risks to advance human knowledge and health.” (Read about Alastair’s experience in the Washington Post.)

Jake Eberts


Shigella flexneri 2a SF2a-TT15 vaccine challenge, 2022

“I’m very proud of my participation. I traded my own health for a little while in the hopes that one day, others won’t have to suffer from dysentery — which I can say from personal experience is not a fun sickness to have!”

Frank Williams


Streptococcus pneumonia challenge, 2021

“It’s very important for us to take part in a fight against diseases by whatever means we can. Developing vaccines to many diseases is the greatest weapon the world can use.“

Keller Scholl


Zika virus dose-finding challenge, 2023

“Human challenge trials can help us understand diseases and vaccines in ways sometimes nothing else can enable. I volunteered because I wanted to help.”

Paul Zimmer-Harwood


Malaria (Plasmodium falciparum) challenge, 2018; SARS-CoV-2 (Wuhan strain) reinfection challenge study, 2021

Marcus Dahl


SARS-CoV-2 (Wuhan strain) reinfection challenge study, 2021

“The pandemic has been tough for everyone, so I was happy to put my hand up to help out. The research team was great, and getting involved became a good opportunity to fundraise for UNICEF’s COVAX global vaccine equity program at the same time.”

Jacob Hopkins


SARS-CoV-2 (Wuhan strain) challenge study, 2021 (The study’s first participant!)

“Like everyone, I just wanted to help. Looking back, I’m like, ‘Yeah, I did that!’ — I made an impact. Challenge trials show people’s readiness to help and how a single act can be huge. I’m grateful for the opportunity to take that risk.”

Carolina Reid


Malaria (Plasmodium falciparum NF54) GAP3KO vaccine challenge, 2018

“Participating in research has been the most fascinating way to connect to the medical world — I learn a lot every time and we make advancements towards a healthier world.”

Reed Shafer-Ray


Covid-19 VXCO-100 vaccine Phase I study, 2023

“I chose to receive an experimental Covid vaccine that could one day make vaccines cheaper, more effective, and more widely accessible. The decision to participate was easy — I would take slight inconvenience for the opportunity to save just one life, much less millions.”

Angelique Mseteka


Malaria (Plasmodium falciparum 7G8) challenge, 2021